Sujeenthar Tharmalingam, PhD
Associate Professor, Medical Sciences Division
Lakehead University Campus
955 Oliver Road
Thunder Bay, Ontario
P7B 5E1
Email: sutharmalingam@nosm.ca
Education and Professional Roles
2016-2018 |
Post-doctoral Fellow, Radiation Biology NOSM University (Sudbury, Canada) |
2014-2015 |
Post-doctoral Fellow, Angiogenesis and Vascularisation Faculty of Health, York University (Toronto, Canada) |
2008-2013 |
PhD, Cancer Biology and Neuroscience Department of Pharmaceutical Sciences, University of Toronto (Toronto, Canada) |
2005-2008 |
B.Sc. Hons, Double Major in Human Biology and Pharmacology University of Toronto (Toronto, Canada) |
Research Interest
- Radiation biology; cancer biology; DNA damage repair;
- Molecular mechanisms underlying radiation resistant cancers;
- Development of rapid diagnostic platforms for clinical applications;
- Expertise: CRISPR gene editing, functional genomics, transcriptomics, epigenetics, proteomics, metabolomics and next-generation sequencing technologies.
Selected Publications
Puukila, S., Tharmalingam, S., Al-Khayyat, W., Peterson, J., Hooker, A. M., Muise, S., Boreham, D. R., and Dixon, D. L. (2021) Transcriptomic Response in the Spleen after Whole-Body Low-Dose X-Ray Irradiation. Radiation research 196, 66-73
Murray, A., Tharmalingam, S., Nguyen, P., and Tai, T. C. (2021) Untargeted metabolomics reveals sex-specific differences in lipid metabolism of adult rats exposed to dexamethasone in utero. Scientific reports 11, 20342
MacLean, A., Legendre, F., Tharmalingam, S., and Appanna, V. D. (2021) Phosphate stress triggers the conversion of glycerol into l-carnitine in Pseudomonas fluorescens. Microbiological research 253, 126865
Davidson, C. Q., Tharmalingam, S., Niccoli, S., Nemec-Bakk, A., Khurana, S., Murray, A., Tai, T. C., Boreham, D. R., Khaper, N., and Lees, S. J. (2020) Dose threshold for radiation induced fetal programming in a mouse model at 4 months of age: Hepatic expression of genes and proteins involved in glucose metabolism and glucose uptake in brown adipose tissue. PloS one 15, e0231650
Tharmalingam, S., Khurana, S., Murray, A., Lamothe, J., and Tai, T. C. (2020) Whole transcriptome analysis of adrenal glands from prenatal glucocorticoid programmed hypertensive rodents. Scientific reports 10, 18755
Zarnke, A. M., Tharmalingam, S., Boreham, D. R., and Brooks, A. L. (2019) BEIR VI radon: The rest of the story. Chemico-biological interactions 301, 81-87
Tharmalingam, S., Sreetharan, S., Brooks, A. L., and Boreham, D. R. (2019) Re-evaluation of the linear no-threshold (LNT) model using new paradigms and modern molecular studies. Chemico-biological interactions 301, 54-67
Scott, B. R., and Tharmalingam, S. (2019) The LNT model for cancer induction is not supported by radiobiological data. Chemico-biological interactions 301, 34-53
Pirkkanen, J., Tharmalingam, S., Morais, I. H., Lam-Sidun, D., Thome, C., Zarnke, A. M., Benjamin, L. V., Losch, A. C., Borgmann, A. J., Sinex, H. C., Mendonca, M. S., and Boreham, D. R. (2019) Transcriptomic profiling of gamma ray induced mutants from the CGL1 human hybrid cell system reveals novel insights into the mechanisms of radiation-induced carcinogenesis. Free radical biology & medicine 145, 300-311