Donate Now!

Dr. Aseem Kumar

profile image placeholder, grey silhouette of a person Northern Ontario School of Medicine
Lakehead University Campus
935 Ramsey Lake Road
Sudbury ON Canada P3E 2C6
Phone:  (705) 522-6237, ext. 2703
Fax:  (705) 523-7326
Email: akumar@laurentian.ca
Professor, Biomolecular Sciences Ph.D. Progam 
Professor,
Department of Chemistry and Biochemistry 
Professor,
Department of Biology 
Professor,
Medical Sciences Division

Education/Training

 2006-2009

Director, Biomolecular Sciences Ph.D. Program (2003-2009)
Canada Research Chair in Biomolecular Sciences (2003-2009)
Biomolecular Sciences Ph.D. Program
Department of Chemistry and Biochemistry
Department of Biology
Northern Ontario School of Medicine , Laurentian University

2003-2005

Biomolecular Sciences Ph.D. Program
Department of Chemistry and Biochemistry
Department of Biology
Northern Ontario School of Medicine, Laurentian University

 1997-2002

Faculty, Division of Cardiovascular Disease and Critical Care Medicine
and Department of Immunology/Microbiology
Rush-Presbyterian-St. Luke’s Medical Center and University

1995-1997

Research Fellow
Department of Cancer Biology, Cleveland Clinic Foundation

1992-1997

Ph.D. Dept. of Molecular and Medical Genetics
Faculty of Medicine, University of Toronto

1990-1992

M. Sc. Dept. of Molecular and Medical Genetics
Faculty of Medicine, University of Toronto

1983-1988

HBSc. Major Programme in Human Biology
Minor Programme in Physiology
Research Investigations

Faculty of Arts and Science, Specialist Programme in Molecular Genetics and Biology
University of Toronto

Identification and Characterization of Sepsis Molecular Signalling Pathways

Sepsis and septic shock represent the overwhelming response to infection. Approximately 800,000 cases of sepsis are admitted every year to hospitals in the North America and despite aggressive antibiotics and supportive care, over 200,000 patients per year succumb to this disorder. Sepsis and sepsis-associated multiple organ failure are the leading cause of death in intensive care units of the developed world and claim over 500,000 lives per year world wide. We are characterizing new initiators and mediators of sepsis and septic shock. These pathways and process include: cytokine signalling, transcription factor modulation, apoptosis, bacterial DNA and RNA signalling and characterization of global gene expression patterns that occur during the disease. To examine these signalling events we have developed a tissue culture model and a mouse model of sepsis and septic shock. We are also studying tissues from spontaneous human sepsis and septic shock.

Research Projects

Cytokine and transcription factor regulation: We are identifying infecting organism(s), cytokine profile (including IFNs, ILs and TNFs) and transcription factor profile (including STAT, IRF and NF-kB) in our models of sepsis. We are currently determining if modulation of these cytokines and transcription factors during the disease will increase viability.

Apoptosis: We have shown that apoptosis occurs during sepsis and septic shock with an increase in caspase gene expression and activation. We are characterizing caspase gene family expression and are employing inhibitors of caspase activation as a drug therapy.

Bacterial DNA and RNA: We have determined that bacterial DNA and RNA induce a depression of myocyte contraction. Regulation of the pathways involved in bacterial DNA and RNA dependent myocyte depression may lead to novel therapeutics.

Global gene expression: We have determined that genes involved in the pro-inflammatory response, cell adhesion molecule regulation, apoptosis and cell cycle control are modulated during sepsis. We are using rationale drug design to alter deleterious gene expression patterns that occur during sepsis and septic shock.

Selected Publications

Maryam Shojaei,  Grant Parnell,  David Booth, Anard Kumar, John Ho, Yoav Keynan, Adrienne, Meyers, T Blake Ball, Amarnath Pisapati, Aseem Kumar, Amy Phu, Stephen Huang, Marek Nalos, Anthony S McLean, Kenneth McPhie, Kate O’Connor, Stephen Schibeci and Benjamin M Tang. IFI27 as a biomarker of severe influenza infection. Manuscript submitted.

Yaseen Arabi, Saqib Dara, Ziad Memish Abdulmajeed Al-Abdulkareem, Hani M. Tamim, Nehad Al-Shirawi, Joseph E. Parrillo, Stephen Lapinski, Daniel Feinstein, Gordon Wood, Sandra Dial, Anand Kumar and The Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group (Aseem Kumar is a member of this group). Antimicrobial Therapeutic Determinants of Outcomes in Patients with Cirrhosis-Associated Septic Shock. Manuscript submitted.

Sheryl Zelenitsky, Ethan Rubinstein, Robert Ariano, Harris Iacovides, Anand Kumar and the Cooperative Antimicrobial Therapy in Septic Shock (CATSS) Database Research Group (Aseem Kumar is a member of this group). Vancomycin Pharmacodynamics and Survival in Patients with Methicillin-Resistant Staphylococcus aureus (MRSA) Septic Shock. Manuscript submitted

Andre Amaral, Robert Fowler, Ruxandra Pinto, Gordon Rubenfeld, Paul Ellis, Brian Bookatz, John Marshall, Greg Martinka, Sean Keenan, Denny Laporta, Daniel Roberts, Anand Kumar and the Cooperative Antimicrobial Therapy in Septic Shock (CATSS) Database Research Group (Aseem Kumar is a member of this group). Patient and organizational characteristics associated with delays in antimicrobial administration for septic shock. Manuscript submitted.

Constantine J. Karvellas, Juan G. Abraldes, Yaseen Arabi, Anand Kumar and the Cooperative Antimicrobial Therapy in Septic Shock (CATSS) Database Research Group (Aseem Kumar is a member of this group). Appropriate and Timely Antimicrobial Therapy in Cirrhotic Patients with Spontaneous Bacterial Peritonitis-Associated Septic Shock: A Retrospective Cohort Study. Manuscript submitted.

Chilakamarti V. Ramana, Matthew DeBerge, Aseem Kumar, Christopher Alia, Joan Durbin and Richard Enelow. Inflammatory Impact of IFN-g in CD8+ T-cell-mediated Lung Injury is Mediated by Both Stat1-dependent and -independent Pathways. In Press, American Journal of Physiology, January 2015.

Sandyha Khurana, Amanda Hollingsworth, Matthew Piche, Krishnan Venkataraman, Aseem Kumar, Gregory M. Ross and T.C. Tai. Methyl Gallate Protects Rat Cardiac Myocytes from H2O2-Mediated Apoptosis. Oxidative Medicine and Cellular Longevity Article ID 657512, pages 1-9, 2014.

Aleksandra Leligdowicz, Peter M. Dodek, Monica Norena, Hubert Wong, Aseem Kumar, Anand Kumar, and The Co-operative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Association between source of infection and hospital mortality in patients who have septic shock. American Journal of Respiratory and Critical Care Medicine 180:10 pages 1204-1213, 2014.

Manish Sood, Keren Mandelzweig, Claudio Rigatto, Navdeep Tangri, Paul Komenda, Gregory Martinka, Yaseen Arabi, Sean Keenan, Aseem Kumar and Anand Kumar for the Cooperative Antimicrobial Therapy in Septic Shock (CATSS) Database Research Group . Non-pulmonary Infections but not Specific Pathogens are Associated with Increased Risk of AKI in Septic Shock. Intensive Care Medicine Vol. 40, Number 8, 1080-1088, 2014.

Duane Funk, Steven Doucette, Amarnath Pisipati, Peter Dodek, John C. Marshall, Anand Kumar and  the Cooperative Antimicrobial Therapy of  Septic Shock (CATSS) Database Research Group (Aseem Kumar is a member of this group).  Low Dose Corticosteroid Treatment in Septic Shock: A Propensity Matching Study. Critical Care Medicine 42(11) 2333-2341, 2014.

Sandyha Khurana, Collin Byrne, Drishnan Venkataraman, Aseem Kumar and T.C. Tai. Recent Advances in Gallate Research. Antioxidant and Cytoprotective Effects in Gallates. Nova Publishing, pages 57-116, 2014.  ISBN: 978-1-63117-072-0

Jason Waechter, Anand Kumar, Stephen Lapinsky, John Marshall, Peter Dodek, Yassin Arabi, Joseph E. Parrillo, Richard Dellinger, Allan Garland and the CATSS Dataase Research Group (Aseem Kumar is a member of this group). Interplay Between Fluids and Vasoactive Agents on Mortality in Septic Shock: A Multicenter, Observational Study. Critical Care Medicine 42(10) 2158-68, 2014.

Vance Beck, Dan Chateau, Gregory Bryson, Amarnath Pispati, Sergio Zanotti, Joseph Parrillo, Anand Kumar. and the Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group (Aseem Kumar is  member of this group). Timing of Vasopressor Initiation and Mortality in Septic Shock: A Cohort Study. Critical Care 18:R97 pages 1-8, 2014.

Manoosh Sood, Leigh Shafer, Julie Ho, Martina Reslerova, Greg Martinka, Sean Keenan, Sandra Dial, Gordon Wood, Claudio Rigatto, Anand Kumar and the Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group (Aseem Kumar is  member of this group).  Early Reversible Acute Injury is Associated with Improved Survival in Septic Shock. Journal of Critical Care, Volume 29, Issue 5, 711-717, 2014.

Paul Michael, Danielle Brabant, Farag Bleiblo, Ramana V. Chilakamarti, TC Tai, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. Influenza A Induced Cellular Signal Transduction Pathways. Journal of Thoracic Disease, 5(2) 132-141, 2013.

Shravan Kethireddy , R. Bruce Light, YazdanMiranejad , Dennis Maki, YaseenArabi, Stephen Lapinsky, David Simon, Aseem Kumar, Joseph E. Parrillo, Anand Kumar for the Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Group. Mycobacterium tuberculosis Septic Shock. Chest 144(2) 474-482, 2013.

Yaseen Arabi, Saqib Dara, Kani Tamim, Asgar Rishu, Abdulrazak Bouchama, Mohammad Khedr, Aseem Kumarand Anand Kumar and The Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Clinical Characteristics, Processes of Care and Outcomes in the Obese Patients with Septic Shock: An International Multicenter Cohort Study. Critical Care Journal 17:R72, 2013.

Farag Bleiblo, Paul Michael, Danielle Brabant, Chilakamarti V. Ramana, TC Tai, Mazen Saleh, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. JAK Kinases are Required for the Bacterial RNA and Poly I:C Induced Tyrosine Phosphorylation of PKR. International Journal of Clinical and Experimental Medicine. 6(1):16-25, 2013.

Emily Rimmer, Anand Kumar, Steve Doucette, Aseem Kumar, Ryan Zarychanski and The Co-operative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group. Act. Prot. C and Septic Shock: A Propensity-Matched Cohort Study. Critical Care Medicine. 40, No. 11, 2974-2981, 2012.

Michael Paul, Bleiblo Farag, Kumar Anand, Kumar Aseem: Not Only a Toll for Viruses, the role of TLR3 in Nonviral Sepsis Induced Cardiac Depression. Critical Care Medicine. 40, 2514-2515, 2012.

Farag Bleiblo, Paul Michael, Danielle Brabant,  Chilakamarti V. Ramana, TC Tai, Mazen Saleh, Joseph E. Parrillo, Anand Kumar and Aseem Kumar.  Bacterial RNA Induces Myocyte Cellular Dysfunction through the Activation of PKR. J. Thoracic Disease, 4, No 2, 114-125, 2012.

Farag Beliblo, Paul Michael, Danielle Brabant, Chilakamarti V. Ramana, TC Tai, Mazen Saleh, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. The Role of Immunostimulatory Nucleic Acids in Septic Shock. International Journal of Clinical and Experimental Medicine, 5(1) 1-23,  2012.

Ismail Cinel, Mustafa Ark, Phillip Dellinger, Tuba Karabacak, Lulufer Tamer, Leyla Cinel, Paul Michael, Shaimaa Hussein, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. Involvement of Rho kinase (ROCK) in Lung Injury Induced by Cecal Ligation and Puncture (CLP).
Featured Article in J. Thoracic Disease with two editorials. 4, No 1, 30-39, 2012.

Danielle Brabant, Paul Michael, Ravin Narain, Mazen Saleh, Anand Kumar, Joseph E. Parrillo and Aseem Kumar. Sepsis Mediated Cellular Dysfunction is Mediated by DFF 40 Induced Apoptosis.
Biochemical and Biophysical Research Communications. 412, 260-265, 2011.

James Crispo, Dominique Ansell, Mathew Piche, Joseph Eibl, Isabella Tai, Aseem Kumar, Gregory Ross and T.C. Tai. Protective Effects of Methyl Gallate on H2O2-induced Apoptosis in  PC12 Cells.
Biochemical and Biophysical Research Communications.  393, 773-778, 2010.

Marya Ahmed, Zhicheng Deng, Shiyong Deng, Aseem Kumar and Ravin Narain. Cationic Glyconanoparticles: Complexation with DNA and Their Cellular Uptake.  Bioconjugate Chemistry.  20(11), 2169-2176, 2009.

Chilakamarti V. Ramana, Guang-Shing Cheng, Aseem Kumar, H.J. Kwon and Richard
Enelow. Alveolar Epithelial Early Growth Response-1 (EGR-1) Expression Triggered by
Activated CD8+ T Cells is Critical for Chemokine Gene Expression and Lung Injury. Molecular Immunology. 47, Issues 2-3, 623-631, 2009.

Anand Kumar, Pau Ellis, Yaseen Arabi, Dan Roberts, Bruce Light, Joseph E. Parrillo, Peter Dodek, Gordon Wood, Aseem Kumar, David Simon, Cheryl Peters, Muhammad Ahasan, Dan Chateau. Initiation of Inappropriate Antimicrobial Therapy Results in a 5-fold Reduction of Survival in Human Septic Shock.
Chest.  136, 1237-1248, 2009.

Shaimaa Hussein, Paul Michael, Amadeo Parissenti, Abdelwahab Omri, Anand Kumar, Joseph E. Parrillo and Aseem Kumar. Late Stage Bacterial Sepsis Induced Gene Profiling. International Journal of Clinical and Experimental Medicine. 2(2), 131-148, 2009.

Bagshaw, S.M. etal. (and the Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group (Aseem Kumar is a member of this group). Acute Kidney Injury in Septic Shock: Clinical Outcomes and Impact of Duration of Hypotension Prior to Initiation of Antimicrobial Therapy.
Intensive Care Medicine. 35, 871-881, 2009.

Catherine Song, Aseem Kumar, Abdel Omri and Mazen Saleh. Bioinformatics Comparison of  Bacterial Secretomes.
Genomics, Proteomics and Bioinformatics. 7, 25-36, 2009.

Anand Kumar and Aseem KumarSepsis and Septic Shock. Editors: A. Gabrielli, J. Layon and M. Yu. Civetta, Taylor and Kirby’s Critical Care 4th Ed. June 2009.

Kumar Anand, Kumar Aseem, Parrillo JE: Myocardial Dysfunction in Sepsis and Septic Shock. Acute Heart Failure Sydnromes: A Practical Approach for Physicians. Editor: Alexandre Mebazaa. Springer-Verlag. June 2008.

Rama Kota, Ramana Chilakamarti and Aseem Kumar. Lipoprotein Lipase in Atherosclerosis. Recent Developments in Signal Transduction Research. Research Signpost, Editor: R. V. Chilakamarti May 2008.

Ramana Chilakamarti, Rama Kota and Aseem Kumar. CD8+ T-cell Recognition and Lung Injury. Recent Developments in Signal Transduction Research. Research Signpost, Editor: R. V. Chilakamarti May 2008.

Majed Halwani, Shanna Blomme, Zacharias E. Suntres, Misagh Alipour, Ali O. Azghani, Aseem Kumar and Abdelwahab Omri. Liposomal Bismuth-Ethanedithiol Formulation Enhances Antimicrobial Activity of Tobramycin.
International Journal of Pharmaceutics, 358, 278-284, 2008.

Marisa Tessier, Paul Michael, Danielle Brabant,  Ramana V. Chilakamarti, Abdel Omri, Mazen Saleh, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. Characterization of Factors in Human Septic Sera that Mediate Cellular Dysfunction.. Recent Developments in Signal Transduction Research. Research Signpost, (refereed paper with original data published as a book chapter)  Editors: Ramana V. Chilakamarti, pages 1-23, May 2008.

Lisa Falvo, Paul Michael, Xiulong Xu, Joseph E. Parrillo, Abdelwahab Omri, Anand Kumar and Aseem Kumar. Human Septic Serum Induced Apoptotic Gene Expression Profile in Human Myocytes. Cell Apoptosis Research Progress, (refereed paper with original data published as a book chapter) Nova Publishing, Editor: Robert H. Fenton, pages 135-152, May 2008.

Kumar Anand and Kumar Aseem: Development of Sepsis Therapeutics and Molecular
Diagnostics. Expert Commentary, Nova Publishing 2008.

Majed Halwani, Clement Mugabe, Ali O. Azghani, Robert M. Lafrenie, Aseem Kumar and Abdelwahab Omri. Bactericidal Efficacy of Liposomal Aminoglycosides against Burkholderia Cenocepacia.
Journal of Antimicrobial Chemotherapy, 60:760-769, October 2007.

Danielle Brabant, Paul Michael, Chilakamarti V. Ramana, Joseph E. Parrillo, Anand Kumar and Aseem Kumar. Characterization of Key Apoptotic Signalling Pathways that Mediate Sepsis Induced Cellular Dysfunction, New Cell Apoptosis Research (refereed paper with original data published as a book chapter at Nova Publishing, Editor. C. Pickens) pages 1-40, July 2007.

Anand Kumar, Bhanu Paladugu, Joel Mensing, Aseem Kumar and Joseph E. Parrillo.  Nitric Oxide-Dependent and -Independent Mechanisms are Involved in TNF-a-Induced Depression of Cardiac Myocyte Contractility.
American Journal of Physiology 292:1900-1906, 2007.

Anand Kumar, Aseem Kumar, Bhanu Paladugu, Joel Mensing and Joseph E. Parrillo.
TGF-b Blocks in-vitro Cardiac Myocyte Depression Induced by TNF-a and IL-1b and Human Septic Shock Serum.
Featured Article Critical Care Medicine Journal 35:358-364, 2007.

Rama S. Kota, Kapilchandra Gohil, Aseem Kumar , Richard  I. Enelow, John C. Rutledge  and  Chilakamarti.V. Ramana. Regulation of gene expression in RAW 264.7 macrophages by Interferon-gamma.
Biochemical and Biophysical Research Communications 342:1137-1146, 2006.

Anand Kumar, Kenneth E. Wood, Robert Suppes, Joseph E. Parrillo, Daniel Feinstein, Satendra Sharma, Sergio Zanotti, Leo Taiberg, David Gurka, Aseem Kumar, Mary Cheang, Bruce Light, Daniel Roberts. Duration of Hypotension Prior to Initiation of Effective Antimicrobial Therapy is the Critical Determinant of Survival in Human Septic Shock.           
Featured Article in Critical Care Medicine Journal 34:1589-1596, 2006.

Anand Kumar, Bhanu Paladugu, Cameron Haery, Aseem Kumar, Simon Symeoneides, Gordon Trenholme, Joanne Sandelski, Steve Opal and Joseph E. Parrillo. Duration of Hypotention Prior to Antibiotic Administration is a Critical Determinant of Outcome in a Murine Model of E. coli Septic Shock.
Major Article in the Journal of Infectious Diseases 193:251-258, 2006.

M. Pilar Gil, Aseem Kumar, Richard I. Enelow and Chilakamarti V. Ramana.  STAT1-independent Pathways in Interferon Signaling. Interferons (editor Kailash Chadha, Roswell Park Cancer Center, Buffalo, NY) 2006.

Aseem Kumar, Anand Kumar, Xiulong Xu and Joseph E. Parrillo.
Human Serum Derived from Patients with Septic Shock Activates Transcription Factors   STAT1, IRF1, NF-kB and Induces Apoptosis in Human Cardiac Myocytes.
J. Biol. Chem. 280:42619-42626, Dec. 2005.

Chilakamarti V. Ramana, Aseem Kumar and Richard Enlow.  STAT1-independent Induction of SOCS-3 by Interferon-g is Mediated by Activated STAT3 in Mouse Embryo Fibroblasts.
Biochemical and Biophysical Research Communications 327:727-733, 2005.

Kumar Anand, and Kumar Aseem: Nitric oxide and inflammatory cytokines in the heart:
The presence of positive feedback loops.
Critical Care Medicine, 33:2851-2852, 2005.

Danielle Brabant, Paul Michael, Marija Tonnos, Marisa Tessier, Shuhung Kung, Anand Kumar, Chilakamarti V. Ramana and Aseem Kumar.  Molecular Biology of Sepsis. Proceedings of the International Biotechnology Symposia.  Haldia Institute of Technology, India, January 2005.

Chilakamarti V. Ramana, Aseem Kumar, Jyothi Chinthrapalli and Richard I. Enelow.  CD8+ T Cell and Alveolar Epithelial Cell Interactions in Lung Injury.  Proceedings of the International Biotechnology Symposia.  Haldia Institute of Technology, India, January 2005.

Bhanu Paladugu, Anand Kumar, Joseph E. Parrillo, Sandy Der, Jailan Osman, Joel Mensing, Lisa Falvo, Xiulong Xu and Aseem Kumar.  Bacterial DNA and RNA Induce Rat Cardiac Myocyte Contraction Depression In-Vitro.
Shock Journal 21(4):364-369, April 2004.

Kumar Anand and Kumar Aseem: Endotoxemic myocardial depression: A novel iNOS suppressing effect of albumin.
Critical Care Medicine, 31:324-326, 2003.

Ping Jiang, Aseem Kumar, Joseph E. Parrillo, Laurie A. Dempsey, Jeffrey L. Platt,
Richard A. Prinz, Xiulong Xu. Transcriptional regulation of heparanase 1 gene expression in thyroid neoplastic cell lines by Sp1.
J. Biol. Chem.  277: 8989-8998,  March 15, 2002.

Aseem Kumar, Anand Kumar and Joseph E. Parrillo.  IL-1 Gene Cluster: All in the Family.
Critical Care Medicine, 30:1168-1169, 2002.

Anand Kumar, Aseem Kumar and Joseph E. Parrillo.  Reversible Myocardial
Dysfunction: A Ubiquitous Phenomena in the Critically Ill?
Critical Care Medicine, 30:1392-1393, 2002.

Zanotti S, Kumar Aseem, Kumar Anand: Experimental and emerging therapies for sepsis and septic shock: Part 2. Cytokine modulation in sepsis and septic shock.
Expert Opinion in Investigational Drugs, 11:1061-1075, 2002.

Manocha S, Feinstein D, Kumar Aseem, Kumar Anand: Experimental and emerging therapies for sepsis and septic shock: Part 3. Anti-endotoxin strategies in gram-negative sepsis and septic shock.
Expert Opinion in Investigational Drugs, 11:1795-1812, 2002

Krishnagopalan S, Kumar Aseem, Parrillo JE, Kumar Anand: Myocardial dysfunction in sepsis and septic shock.
Current Opinion in Critical Care, 5:376-388, 2002.

Court O, Kumar Aseem, Parrillo JE, Kumar Anand: Myocardial dysfunction in the septic patient.
Critical Care Medicine, 6:500-508, 2002

Anand Kumar, Ana Krieger, Simon Symeoneides, Aseem Kumar and Joseph E. Parrillo.
Myocardial Dysfunction in Septic Shock: Part II. Roles of Cytokines and Nitric Oxide.
Journal of Cardiothoracic and Vascular Anesthesia, Vol 15, No 4 (August), 2001: pp 485-511.

Xiao Rui Li, Anita Chong, Jianming Wu, Kenneth A. Roebuck, Aseem Kumar, Joseph E. Parrillo, Ulf R. Rapp, Robert P. Kimberly, James W. Williams and Xiulong Xu.  Transcriptional Regulation of Fas Gene Expression by GA Binding Protein (GABP) and AP1 in T Cell Antigen Receptor (TCR)/CD3 Complex-Stimulated T Cells.
J. Biol. Chem.  274, 35203-35210, December 3, 1999.

Anand Kumar, Aseem Kumar and Joseph E. Parrillo. Cytokines and Septic Myocardial
Depression:  Nitric Oxide vs. Sphingosine/Ceramide? 
Critical Care Medicine, 27:1391-1393, 1999.

Aseem Kumar, Anand Kumar, G Skorupa, M Vukonich, B Paladugu,  P Narang, C.Haery, H. Merchant and J E Parrillo.Characterzation Of Intracellular Signalling
Components Involved in Sepsis. Nature  Biotechnology Short Reports, Volume 10 :   Advances in Gene Technology; Signal transduction & therapeutic strategies, 1999;10:74

Kumar Anand, Kumar Aseem, G Skorupa, Vukonich M, Paladugu B, Saleem A, Narang P, Parvathala P, R Battula, R Makkena, Haery C, And Parrillo JE. Early human septic serum-induced cardiac myocyte depression is caused by synergestic stimulation of a constitutive nitric oxide synthase by TNF-Alpha and IL-1Beta
Nature Biotechnology Short  Reports, Volume 10: Advances in Gene Technology;
Signal transduction and therapeutic strategies,1999;10:39.

Aseem Kumar, Mairead Commane, Thomas Flickinger, Curt Horbath, and George R. Stark.  Defective TNF-a-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases.
Science, 278, 1630-1632, November 28, 1997.
News and Views, 1541, ibid.
Perspective, 1578-1579, ibid.

Aseem Kumar, Yi-li Yang, Vincenzo Flati, Sandy Der, Suzanne Kadereit, Jaharul Haque, Amitabha Deb, Luiz Reis, Charles Weissmann and Bryan R.G. Williams.
Deficient Cytokine Signalling in Mouse Embryo Fibroblasts with a Targeted Deletion in the PKR Gene.
EMBO J. 16, 406-416, January 15, 1997.

Michael Rutherford, Aseem Kumar, Jaharul S. Haque and Bryan R.G. Williams.
Proto-oncogene Ets-1 Specifically Binds the ISRE of 2-5A Synthetase.
Journal of IFN and Cytokine Research 17, 1-10, 1997.
[The first two authors contributed equally to the paper and should be considered as first co-authors].

Michael Rutherford, Aseem Kumar, Benoit Coulombe, Dan Skup, Dave Carver and Bryan R.G. Williams.  Intracellular Interferon Constituitively Activates ISGF3 and Confers Resistance to EMC Viral Infection.
Journal of IFN and Cytokine Research 16, 507-510, July 1996.
[The first two authors contributed equally to the paper and should be considered as first co-authors].

Jaharul S. Haque, Heiko van der Kuip, Aseem Kumar, Walter E. Aulitzky, Michael N. Rutherford, Christopher Huber,  Thomas Fischer, and Bryan R.G. Williams. Overexpression of Mouse p140-Subunit of Replication Factor C Accelerates Cellular Proliferation.
Cell Growth and Differentiation 7,319-326, March 1996.

Paul F. Torrence, Wei Xiao, Guiying Li, Shahrzad Khamnei, Krystyna Lesiak, Avudaiappan Maran, Ratan Maitra, Aseem Kumar, Beihua Dong, Bryan R. G. Williams and Robert H. Silverman. Targeting RNA for Degradation with a (2′,5′)-oligoadenylate Antisense Chimera.
Nucleosides and Nucleotides, 14(3-5), 1073-1076 (1995).

Yi-Li Yang, Luiz Reis, Jovin Pavlovic, Adriano Aguzzi, Reinhold Schafer, Aseem Kumar, Bryan R.G. Williams, Michel Auget and Charles Weissmann.  Deficient Signalling in Mice Devoid of Double-stranded RNA-dependent Protein Kinase, PKR.
EMBO J. Vol. 14, no. 24, 6095-6106, December 15, 1995.

Cornelius F. Waller,M.D., Ratan K. Maitra, Ph.D., Avudaiappan Maran, Ph.D., Aseem Kumar, M.Sc., Beihua Dong, M.Sc., Wei Xiao, Ph.D., Guiying Li, Ph.D., Bryan R.G. Williams,Ph.D., Paul F. Torrence, Ph.D. and Robert H. Silverman, Ph.D.  2-5A-Anti-sense a Novel Approach to Cancer Therapy.
Biology of Renal Cell Carcinoma, Springer-Verlag, 133-148 (1995).

A. Maran, R.K. Maitra, A.Kumar, B. Dong, W. Xiao, B.R.G. Williams, P.F. Torrence and R.H. Silverman.  Blockage of NF-kB Signaling By Selective Ablation of an mRNA Target by 2-5A-Antisense Chimeras.
Science, Vol. 265, 789-792, August 5, 1994.

Aseem Kumar, Jaharul S. Haque, Judith Lacoste, John Hiscott and Bryan R.G.Williams. The dsRNA-Dependent Protein Kinase, PKR, Activates Transcription Factor NF-kB by Phosphorylating IkB.
Proc. Natl. Acad. Sci. USA, Vol. 91, 6288-6292, July 5, 1994.

Gengsheng Feng, Karen Chong, Aseem Kumar and Bryan R.G. Williams.
Identification of dsRNA Binding Domains of the Interferon Induced Protein Kinase.
Proc. Natl. Acad. Sci. USA, Vol. 89,5447-5451, June 1992.

Michael N. Rutherford, Aseem Kumar, Ahuva Nissim, Judith Chebath and Bryan R.G. Williams. The Murine 2-5A Synthetase Locus:  Three Distinct Transcripts From Two Linked Genes.
Nucleic Acids Research, Vol. 19, 1917-1924, #8, 1991.

Book Editorships

Editors: Chilakamarti V. Ramana, Ph.D. and Aseem Kumar, Ph.D. Recent Developments in Signal Transduction Research.  Research Signpost. May 2008. ISBN:978-81-308-0264-0