Alexander R. Moise, PhD
Professor, Medical Sciences Division
Lakehead University Campus
955 Oliver Road
Thunder Bay, Ontario
P7B 5E1
Phone: 705-662-7253
Email: amoise@nosm.ca
Education and Professional Roles
2016-2017 |
Associate Professor, Pharmacology and Toxicology University of Kansas, Lawrence, Kansas |
2009-2016 |
Assistant Professor, Pharmacology and Toxicology University of Kansas, Lawrence, Kansas |
2007-2009 |
Instructor, Department of Pharmacology Case Western Reserve University, Cleveland, Ohio, USA |
2003-2005 |
Postdoctoral fellowship, Ophthalmology University of Washington, Seattle, Washington |
2000 – 2002 |
University of British Columbia, Biotechnology Laboratory (Michael Smith Laboratories), Vancouver, British Columbia, Canada; Postdoctoral Scholar |
1994 – 2000 |
University of British Columbia, Vancouver, British Columbia, Canada; Ph.D. in Zoology |
| 1989 – 1994 | University of British Columbia, Vancouver, British Columbia, Canada;
Honours B.Sc. in Genetics (Biology) |
Research Interest
My research examines how nutrients and other small molecules influence physiology, development, and disease at the molecular and cellular level. I am interested in the biochemical pathways that regulate metabolism, signaling, and tissue function, and in how these processes can be studied to better understand human health and disease. My work spans biochemistry, molecular biology, cell biology, and physiology, and offers students opportunities for training in both fundamental and applied biomedical research.
I am currently accepting thesis students, graduate students at the Masters and Ph.D. levels, and students interested in summer research projects. Trainees with interests in biochemistry, molecular biology, nutrition, metabolism, and related areas of biomedical science are encouraged to get in touch.
Selected Publications
Billings SE, Pierzchalski K, Tjaden NEB, Pang XY, Trainor PA, Kane MA, Moise AR. The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. FASEB Journal. 2013. doi: 10.1096/fj.13-227967
Moise AR, Al-Babili S, Wurtzel ET. Mechanistic Aspects of Carotenoid Biosynthesis. Chemical Reviews. 2014. doi: 10.1021/cr400106y
Pang XY, Cao J, Addington L, Lovell S, Battaile KP, Zhang N, Rao J, Dennis EA, Moise AR. Structure/Function Relationships of Adipose Phospholipase A2 Containing a Cys-His-His Catalytic Triad. Journal of Biological Chemistry. 2012. doi: 10.1074/jbc.M112.398859
Pang XY, Wang S, Jurczak MJ, Shulman GI, Moise AR. Retinol saturase modulates lipid metabolism and the production of reactive oxygen species. Archives of Biochemistry and Biophysics. 2017. doi: 10.1016/j.abb.2017.09.009
Wang S, Yu J, Jones JW, Pierzchalski K, Kane MA, Trainor PA, Xavier-Neto J, Moise AR. Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells. FASEB Journal. 2018. doi: 10.1096/fj.201701038R
O Connor C, Varshosaz P, Moise AR. Mechanisms of Feedback Regulation of Vitamin A Metabolism. Nutrients. 2022. doi: 10.3390/nu14061312
Varshosaz P, O Connor C, Moise AR. Feedback regulation of retinaldehyde reductase DHRS3, a critical determinant of retinoic acid homeostasis. FEBS Letters. 2025. doi: 10.1002/1873-3468.15038
Selected Media Coverage
2024 Fellow, International Carotenoid Society, International Carotenoid Society
2021 NOSM Scholar Award, Northern Ontario School of Medicine
2015 Fulbright U.S. Scholar Award, Brazil, U.S. Department of State Bureau of Educational and Cultural Affairs / Commission for Educational Exchange between the United States and Brazil / CAPES
2014 Leading Light Award, University of Kansas
Social Media and Websites
ORCID: 0000-0003-2307-6035
Researcher ID: C-9498-2009
https://scholar.google.ca/citations?user=cZJQX3kAAAAJ&hl=en