Carita Lannér, PhD

Professor Emeritus, Medical Sciences Division

NOSM University in Sudbury
935 Ramsey Lake Road
Sudbury, ON
P3E 2C6

Phone: (705) 662-7238
Fax: (705) 675-4858
Email: clanner@nosm.ca

Education and Professional Roles

Professor Emeritus, NOSM University Associate Professor of Molecular Genetics, Northern Ontario School of Medicine Cross-Appointment in the Department of Biology, Laurentian University Cross-Appointment in the Department of Chemistry and Biochemistry, Laurentian University Core Faculty in the Biomolecular Sciences Program, Laurentian University Associate Professor, Laurentian University

2003-2004: Assistant Scientist/Assistant Professor,Division of Hematology/Oncology, Indiana University School of Medicine, Department of Medicine, Indianapolis, Indiana

2001-2003: Assistant Scientist/Assistant Professor, , Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana

1999-2000: Post Doctoral Fellow, Wells Center for Pediatric Research, Indiana University, School of Medicine, Indianapolis, Indiana

1997-1999: Post Doctoral Fellow, Department of Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana

1997: PhD, Department of Plant Breeding Research, Swedish University of Agricultural Sciences, Svalöv, Sweden

1983: M.Sc., Department of Genetics, The Ohio State University, Columbus, Ohio

1977: B.Sc., Faculty of Natural Sciences, The University of Lund, Lund, Sweden

 

Research Interest

Mechanisms of tumor cell response to chemotherapy drugs I am interested in the genetic changes in ovarian tumors that lead to the development of drug resistance. To study this, my lab has developed ovarian cancer cell lines, resistant to the most common types of drugs used to treat ovarian cancer, which can be used to study how this problem develops at a molecular level. The goal is to find changes that can be used as biomarkers to predict patient response and which may become therapeutic targets for treatment of ovarian cancer. Another aspect of my research has occurred through a collaboration with Dr. A. Parissenti, working at the Sudbury Health Sciences North Research Institute. We are working on a drug response biomarker that can be used to determine if a patient’s tumor is responding to chemotherapy. The biomarker is based on ribosomal RNA which becomes systematically degraded or disrupted when tumor cells are dying from chemotherapy treatment. The marker is called the RNA Disruption Index (RDI). My lab is working on understanding the molecular mechanisms underlying RDI, so we can improve detection of chemotherapy response in patients, which can be used to guide treatment.

Selected Publications

Sehorinho, G.N.A., Lanner, C., Scott, J.A. (2018) The influence of harvesting time on the antibacterial activity of green microalgal extracts and their effect on non-malignant and malignant cells viability. Phycological Research , DOI 10.1111/pre.12362.

Edwardson, D.W.; Boudreau, J., Mapletoft, J., Lanner, C., Kovala, A.T., Parissenti, A.M. (2017) Inflammatory cytokine production in tumor cells upon chemotherapy drug exposure or upon selection for drug resistance. PLOS ONE https://doi.org/10.1371/journal.pone.0183662 September 15, 2017

Narendrula, R., Mispel-Beyer, K., Guo, B., Parissenti, A., Pritzker, L., Pritzker, K., Masilamani, T., Wang, X., Lannér, C. (2016) RNA disruption is associated with response to multiple classes of chemotherapy drugs in tumor cell lines. BMC Cancer 16: 146.

Dai, H., Hickey, R.J., Liu, J., Bigsby, R.M., Lanner, C., and Malkas, L.H. (2013) Error-promoting DNA synthesis in ovarian cancer cells. Gynecologic Oncology 131(1): 198-206.

Armstrong, S.R., Narendrula, R., Guo, B., Parissenti, A., McCallum, K.L., Cull, S., and Lannér, C. (2012) Distinct genetic alterations occur in ovarian tumor cells selected for combined resistance to carboplatin and docetaxel. Journal of Ovarian Research 5:40.

Sprowl, J.A., Reed, K., Armstrong, S. Lanner, C., Guo, B., Kalatskaya, I., Stein, L., Hembruff, S.L., and Parissenti, A.M. (2012) Alterations in tumour necrosis factor signaling: Pathways associated with cytotoxicity and resistance to taxanes in tumour cells. Breast Cancer Research 14(1):p.R2 [Epub]

Richard ,C., Lannér, C., Naryzhny, S. N. , Sherman , L., Lee , H.,  Lambert, P., and Zehbe, I. (2010) The immortalizing and transforming ability of two common human papillomavirus 16 E6 variants with different prevalences in cervical cancer Oncogene 29(23): 3435-3445.

Wang, Z., Lannér, C., Jin, N., Swartz, D., Li, L., and Rhoades, R. (2003) Hypoxia inhibits myosin phosphatase in pulmonary arterial smooth muscle cells: Role of Rho-kinase. American Journal of Respiratory Cell and Molecular Biology 29: 465-471.

Carr, A., Schmidt, A., Suzuki, Y., del Monte, F., Sato, Y., Lannér, C., Breeden, K., Jing, S., Allen, P., Greengard, P., Yatani, A., Hoit, B., Grupp, I., Hajjar, R., DePaoli-Roach, A., and Kranias, E. (2002) Type 1 phosphatase, a negative inhibitor of cardiac function. Molecular and Cellular Biology 22: 4124-4135.

Lannér, C., Suzuki, Y., Bi, C., Zhang, H., Cooper, L., Bowker-Kinley, M., and DePaoli-Roach, A. (2001). Gene structure and expression of the targeting subunit, RGL, of the muscle-specific gylcogen-associated type 1 protein phosphatase, PP1G. Archives of Biochemistry and Biophysics 388: 135-145.

Suzuki, Y, Lannér, C., Kim, J., Vilardo, P., Zhang, H., Yang, J., Cooper, L., Steele, M., Kennedy, A., Bock, C., Scrimgeour, A., Lawrence, J., and DePaoli-Roach, A. (2001) Insulin control of glycogen metabolism in knockout mice lacking the muscle specific protein phosphatase PP1G/RGL. Molecular and Cellular Biology 21(8): 2683-2694.

Lannér, C. (1998) Relationships of wild Brassica species with chromosome number 2n=18, based on comparison of a chloroplast DNA sequence. Canadian Journal of Botany 76: 228-237.

Lannér, C., Bryngelsson, T., and Gustafsson, M. (1997) Relationships of wild Brassica species with chromosome number 2n=18, based on RFLP studies. Genome 40: 302-308.

Lannér, C., Bryngelsson, T., and Gustafsson, M. (1996) Genetic validity of RAPD markers at the intra- and interspecific level in wild Brassica species with n=9. Theoretical and Applied Genetics 93: 9-14.

Lannér-Herrera, C., Gustafsson, M., Fält,A.-S., and Bryngelsson, T. (1996) Diversity in natural populations of wild Brassica oleracea as estimated by isozyme and RAPD analysis. Genetic Resources and Crop Evolution 43: 13-23.

Olin-Fatih, M., Lannér-Herrera, C., and Lindgren, H. (1996) Analysis of chromosome, mtDNA, and cpDNA patterns in five somatic hybrids between Brassica alboglabra Bailey and Brassica campestris L. Euphytica 90: 281-288.

Chen, B. Y., Simonsen, V., Lannér-Herrera, C., and Heneen, W. (1992) A Brassica campestris-alboglabra addition line and its use for gene mapping, intergenomic transfer and generation of trisomics. Theoretical and Applied Genetics 84: 592-599.