Alexander R. Moise, PhD
Professor, Medical Sciences Division
NOSM University in Sudbury
935 Ramsey Lake Road
Sudbury, ON
P3E 2C6
Phone: 705-662-7253
Email: amoise@nosm.ca
Education and Professional Roles
| 2024 – Present Assistant Dean, Graduate Studies, NOSM University, Sudbury, ON, Canada |
| 2024 – present NOSM University, Sudbury, Ontario, Canada; Professor, Medical Sciences Division |
| 2018 – Present Cross-Appointed Faculty Member, School of Natural Sciences, Laurentian University, Sudbury, ON, Canada |
| 2018 – Present Faculty Member, Biomolecular Sciences Graduate Program, Laurentian University, Sudbury, ON, Canada |
| 2017 – 2024 NOSM University, Sudbury, Ontario, Canada; Associate Professor, Medical Sciences Division |
| 2016 – 2017 University of Kansas, Lawrence, Kansas, USA; Associate Professor, Department of Pharmacology and Toxicology |
| 2009 – 2016 University of Kansas, Lawrence, Kansas, USA; Assistant Professor, Department of Pharmacology and Toxicology |
| 2007 -2009 Case Western Reserve University School of Medicine, Cleveland, Ohio, USA; Instructor, Department of Pharmacology |
| 2005 – 2007 Case Western Reserve University School of Medicine, Department of Pharmacology, Cleveland, Ohio, USA; Postdoctoral Scholar |
| 2002 – 2005 University of Washington Medical Center, Department of Ophthalmology, Seattle, Washington, USA; Postdoctoral Scholar |
| 2000 – 2002 University of British Columbia, Biotechnology Laboratory (Michael Smith Laboratories), Vancouver, British Columbia, Canada; Postdoctoral Scholar |
| 1994 – 2000 University of British Columbia, Vancouver, British Columbia, Canada; Ph.D. in Zoology |
| 1989 – 1994 University of British Columbia, Vancouver, British Columbia, Canada; Honours B.Sc. in Genetics (Biology) |
Research Interest
| My research examines how nutrients and other small molecules influence physiology, development, and disease at the molecular and cellular level. I am interested in the biochemical pathways that regulate metabolism, signaling, and tissue function, and in how these processes can be studied to better understand human health and disease. My work spans biochemistry, molecular biology, cell biology, and physiology, and offers students opportunities for training in both fundamental and applied biomedical research.
Vitamin A and retinoid metabolism, including regulation of retinoic acid homeostasis and signaling. Currently accepting undergraduate, Master’s, and Ph.D. students for research training opportunities. The number of available positions varies depending on project fit, funding, and timing. Prospective trainees with interests aligned with the laboratory’s research areas are encouraged to inquire. |
Selected Publications
Hashimoto AS, Yu J, Williams C, et al. Identification and characterization of short-chain dehydrogenase/reductase 3 (DHRS3) deficiency, a retinoic acid embryopathy of humans. Genet Med Open. 2025;3:103427. PMID: 40519748.
Varshosaz P, O’Connor C, Moise AR. Feedback regulation of retinaldehyde reductase DHRS3, a critical determinant of retinoic acid homeostasis. FEBS Lett. 2025;599:340-351. PMID: 39420244.
Moise AR, Bandara S, von Lintig J. Carotenoid modifying enzymes in metazoans. Methods Enzymol. 2022;674:405-445. PMID: 36008015.
O’Connor C, Varshosaz P, Moise AR. Mechanisms of feedback regulation of vitamin A metabolism. Nutrients. 2022;14(6):1312. PMID: 35334970.
Wang S, Yu J, Kane MA, Moise AR. Modulation of retinoid signaling: therapeutic opportunities in organ fibrosis and repair. Pharmacol Ther. 2020;205:107415. PMID: 31629008.
Wang S, Huang W, Castillo HA, Kane MA, Xavier-Neto J, Trainor PA, Moise AR. Alterations in retinoic acid signaling affect the development of the mouse coronary vasculature. Dev Dyn. 2018;247:976-991. PMID: 29806219.
Wang S, Yu J, Jones JW, Pierzchalski K, Kane MA, Trainor PA, Xavier-Neto J, Moise AR. Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells. FASEB J. 2018;32:3765-3781. PMID: 29447006.
Moise AR, Al-Babili S, Wurtzel ET. Mechanistic aspects of carotenoid biosynthesis. Chem Rev. 2014;114:164-193. PMID: 24175570.
Billings SE, Pierzchalski K, Butler Tjaden NE, Pang XY, Trainor PA, Kane MA, Moise AR. The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. FASEB J. 2013;27:4877-4889. PMID: 24005908.
Moise AR, Al-Babili S, Wurtzel ET. Mechanistic Aspects of Carotenoid Biosynthesis. Chemical Reviews. 2014. doi: 10.1021/cr400106y
Pang XY, Cao J, Addington L, Lovell S, Battaile KP, Zhang N, Rao J, Dennis EA, Moise AR. Structure/Function Relationships of Adipose Phospholipase A2 Containing a Cys-His-His Catalytic Triad. Journal of Biological Chemistry. 2012. doi: 10.1074/jbc.M112.398859
Pang XY, Wang S, Jurczak MJ, Shulman GI, Moise AR. Retinol saturase modulates lipid metabolism and the production of reactive oxygen species. Archives of Biochemistry and Biophysics. 2017;633:93-102. PMID: 28927883.
Selected Media Coverage
| 2024 Fellow, International Carotenoid Society, International Carotenoid Society
2024 Chair, Seventh International Retinoid Conference, FASEB Science Research Conference 2023 CIHR Outstanding Reviewer, Canadian Institutes of Health Research 2021 NOSM Scholar Award, Northern Ontario School of Medicine 2020 Distinguished Speaker, Center for Translational Vision Research, University of California, Irvine 2015 Fulbright U.S. Scholar Award, Brazil, U.S. Department of State Bureau of Educational and Cultural Affairs / Commission for Educational Exchange between the United States and Brazil / CAPES 2014 Leading Light Award, University of Kansas |
Social Media and Websites
| ORCID: 0000-0003-2307-6035 Researcher ID: C-9498-2009https://scholar.google.ca/citations?user=cZJQX3kAAAAJ&hl=en |