Roxanne Deslauriers, PhD

NOSM University
955 Oliver Road
Thunder Bay ON  P7B 5E1  Canada

1972

1968

Prior to my work with NRC, I was involved in scientific research from 1972 – 1999.  My research included:

• the application of non-invasive techniques, magnetic resonance spectroscopy and imaging (MRS, MRI), to solve problems of biological and medical importance; and
• the development of animal models of human diseases as well as technical developments to improve NMR spectroscopy of living animals and humans.

Over 200 peer-reviewed scientific publications. (Complete list available upon request.)

Wang, L., Deng, J., Tian, W., Xiang, B., Yang, T., Li, G., Wang, J., Gruwel, M., Kashour, T., Rendell, J., Glogowski, M., Tomanek, B., Freed, D., Deslauriers, R., Arora, R.C. and Tian, G.Adipose-derived stem cells are an effective cell candidate for treatment of heart failure: an MR imaging study of rat hearts.  American Journal of Physiology: Heart and Circulation Physiology   297: H1020-H1031, 2009

Li, G., Dai, G., Xiang, B., Mark, J., Tomanek, B., Liu, H. and Deslauriers, R. Mapping myocardial viability using interleaved T1-T2* weighted imaging.  International Journal of Cardiovascular Imaging   20: 135-143, 2004

Tian, G., Xiang, B., Dai, G., Li, G., Sun, J., Summers, R. and Deslauriers, R. Retrograde cardioplegia.  Journal of Thoracic and Cardiovascular Surgery   125: 872-880, 2003

Somorjai, R.L., Dolenko, B., Nikulin, A., Nickerson, P., Rush, D., Shaw, A., Glogowski, M., Rendell, J. and Deslauriers, R. Distinguishing normal from rejecting renal allografts: application of a three-stage classification strategy to MR and IR spectra of urine.  Vibrational Spectroscopy   28: 97-102, 2002

Tian, G., Xiang, B., Dai, G., Sun, J., Lindsay, W. and Deslauriers, R. Simultaneous antegrade/retrograde cardioplegia protects myocardium distal to a coronary occlusion: A study in isolated pig hearts.  Magnetic Resonance in Medicine   46: 773-780, 2001

Docherty, J.C., Yang, L., Pierce, G.N. and Deslauriers, R. Na⁺-H⁺ exchange inhibition at reperfusion is cardioprotective during myocardial ischemia-reperfusion; ³¹P NMR studies.  Molecular and Cellular Biochemistry   176: 257-264, 1997

Kupriyanov, V.V., St-Jean, M., Xiang, B., Butler, K.W. and Deslauriers, R. Protective effect of amiloride during hypothermic hyperkalemic preservation: A ³¹P NMR study in isolated pig hearts.  Journal of Molecular and Cellular Cardiology   27: 2237-2248, 1995

Kupriyanov, V.V., Stewart, L.C., Xiang, B., Kwak, J. and Deslauriers, R. Pathways of Rb⁺ influx and their relation to intracellular [Na⁺] in the perfused rat heart: A ⁸⁷Rb and ²³Na NMR Study.  Circulation Research   76: 839-851, 1995

Lareau, S., Boyle, A., Deslauriers, R., Keon, W.J., Kroft, T. and Labow, R.S. Magnesium enhances function of postischaemic human myocardial tissue.  Cardiovascular Research   27: 1009-1014, 1993

Lareau, S., Labow, R.S., Mainwood, G.W., Moore, R., Keon, W.J. and Deslauriers, R. An NMR probe to study function and metabolism simultaneously in isolated human cardiac tissue.  Magnetic Resonance in Medicine   20: 312-318, 1991

Storey, K.B., Miceli, M., Butler, K.W., Smith, I.C.P. and Deslauriers, R.³¹P-NMR studies of the freeze-tolerant larvae of the gall fly, Eurosta solidaginis.  European Journal of Biochemistry   142: 591-595, 1984

Deslauriers, R., Ekiel, I., Kroft, T. and Smith, I.C.P. NMR studies of malaria.  ³¹P nuclear magnetic resonance of blood from mice infected with Plasmodium berghei.  Biochimica et Biophysica Acta   721: 449-457, 1982

Jarrell, H.C., Deslauriers, R., McGregor, W.H. and Smith, I.C.P. Interaction of opioid peptides with model membranes:  a ¹³C NMR study of enkephalin binding to phosphatidyl serine.  Biochemistry   19: 385-390, 1980

Deslauriers, R., Leach, S.J., Maxfield, F.R., Minasian, E., McQuie, J.R., Meinwald, Y.C., Némethy, G., Pottle, M.S., Rae, I.D., Scheraga, H.A., Stimson, E.R. and Van Nispen, J.W.Cyclized depeptide model for a β-bend.  Proceedings of the National Academy of Sciences of the United States of America   76(6): 2512-2514, 1979

Deslauriers, R., Somorjai, R.L. and Ralston, E. Correlation between the x-ray structure of melanostatin and its conformation in solution.  Nature   266: 746-748, 1977

Deslauriers, R., Walter, R. and Smith, I.C.P. Long-range pH-dependent effects on the carbon-13 nuclear magnetic resonance spectra of oxytocin.  Proceedings of the National Academy of Sciences of the United States of America   71: 265-268, 1974

Walter, R., Prasad, K.U.M., Deslauriers, R. and Smith, I.C.P. Conformational studies of oxytocin, lysine vasopressin, arginine vasopressin, and arginine vasotocin by carbon-13 nuclear magnetic resonance spectroscopy.  Proceedings of the National Academy of Sciences of the United States of America   70: 2086-2090, 1973